Fri Aug 22 2025

63 articles - From Friday Aug 15 2025 to Friday Aug 22 2025

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Patient-Reported Outcome Measures Poorly Correlate with Objective Inflammatory Bowel Disease Activity Measures: A Systematic Review.

Although current PROMs offer valuable complementary insights into IBD control from the patient's perspective, they cannot replace objective measures of IBD activity. Future research should focus on refining PROMs and generating composite indices to improve their accuracy and usefulness.

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Pancreas

Total Pancreatectomy with Islet Autotransplantation for Chronic Pancreatitis in Adults: A Systematic Review.

TPIAT improves QoL and pain outcomes in CP patients. Future studies should focus on identifying predictors of successful outcomes and exploring the impact of TPIAT on specific patient subgroups.

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Pancreatology

Endoscopic ultrasound-guided celiac plexus block for painful chronic pancreatitis: A systematic review and meta-analysis.

EUS-CPB provides pain relief in 53% of patients with painful CP and the effect lasts on average for 3 months. A sham-controlled clinical trial is needed to determine the analgesic efficacy of EUS-CPB for pain in CP.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Global metabolite profiling in feces, serum, and urine yields insights into energy balance phenotypes induced by diet-driven microbiome remodeling.

These findings lay the foundation for unveiling causal pathways linking diet-microbiota co-metabolism to energy absorption. NCT02939703

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Heme iron versus ferrous iron salts to treat iron deficiency anemia in Gambian children: randomized controlled trial.

There was no benefit of HIP on the primary endpoints of hemoglobin and ferritin. However, HIP was superior to ferrous sulfate for 5 secondary measures of iron status and might therefore improve iron supply to rapidly developing organs.

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Retail prices, environmental footprints, and nutritional profiles of commonly sold retail food items in 181 countries.

Our finding that higher-priced items have larger environmental footprints is contrary to expectations that a more sustainable diet would be more expensive. Instead, we find that within each food group, meeting dietary needs with lower environmental footprints is possible by choosing items with a lower unit price. These findings are consistent with prior observations that higher-priced items typically use more resources, including energy and water, but may or may not be healthful as measured by nutrient profile scores.

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Inflamm Bowel Dis

Bayesian Statistics: A Narrative Review on Application in Inflammatory Bowel Diseases.

These methods are also applied in pharmacokinetic decision-making to address inter-patient variability in IBD, offering more accurate predictions of drug concentrations and target attainment at the outset of treatment. A checklist is added for non-specialist readers on how to approach reading an article that employs Bayesian methods, as part of a Users' Guide to the Literature.

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Identifying Potential Targets for the Interception of Inflammatory Bowel Disease: Toward Precision Prevention.

While most evidence to date has focused on CD, we also review preclinical insights relevant to UC. As the field moves toward earlier identification of at-risk individuals, the concept of "precision prevention"-matching interventions to individual risk and biology-may ultimately shift the paradigm of IBD care from treatment to prevention.

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Real-World Experience with Upadacitinib for Pediatric Acute Severe Ulcerative Colitis: An International Multicenter Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN.

Twelve patients reported AEs, including two serious AEs of an appendiceal neuroendocrine tumor and cytomegalovirus colitis. Upadacitinib is an effective induction therapy for children and adolescents with ASC after failing anti-TNF.

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Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis.

Increased gut permeability and microbial dysbiosis in UC elevate the serum level of LPS and IL-1, inducing myeloid skewing of HSPCs with an immune memory. Generation of inflammatory potential myeloid cells causes NETs accumulation and aggravates periodontal destruction in the UC-related periodontitis.

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J Crohns Colitis

Early Reduction in Rectal Wall Thickness on Transperineal Ultrasound Predicts Mucosal Healing in Ulcerative Colitis.

Assessing the rectal wall thickness at week 1 is valuable for predicting advanced therapy-induced CER and HEMI in patients with UC. Clinical trials registry number UMIN000032422 ( recptno=R000036970).

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Impact of Concomitant Corticosteroid Use on Adverse Events in Ulcerative Colitis Clinical Trials.

Corticosteroid use is independently associated with increased AEs in UC clinical trials. Continued monitoring and strategies for corticosteroid tapering may reduce AE burden.

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Is 2nd JAKi treatment for UC worth the effort? A retrospective, multi-Centre UK study.

Type of first JAKi failure did not appear to influence clinical remission. No new safety signals were found.

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Longitudinal Profiles of Fecal Calprotectin and C-Reactive Protein in Relation to Outcomes in Crohn's Disease Patients on Infliximab.

Patients under IFX therapy with near or above-threshold FCAL levels or a history of high CRP were more likely to experience adverse outcomes. Regression analyses demonstrated that class membership provided additional prognostic value beyond baseline variables alone. These findings highlight the clinical relevance of trajectory-based monitoring for optimizing treatment strategies and underscore the importance of controlling inflammation early to prevent disease progression in CD.

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Micronutrients are associated with endoscopic postoperative recurrence in Crohn's disease: a multicenter prospective cohort study in North america.

A machine-learning model combining nutrient intake and clinical factors enhanced the prediction of ePOR. These findings highlight the importance of postoperative nutritional assessment and suggest dietary interventions may help prevent postoperative recurrence in CD.

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Phenome-wide association study of monogenic inflammatory bowel disease genes in diverse biobanks identifies population-specific and shared Goldilocks alleles: implications for Precision Medicine.

We define overlap between monogenic and genome-wide IBD loci and reveal population-specific allelic heterogeneity of IBD risk genes. We uncover novel phenotype associations suggesting pleiotropic effects of monogenic IBD genes. African-predominant variants revealed allelic associations absent in European cohorts, and of potential clinical significance, underscoring the importance of increasing diversity in genetic studies.

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Results of the 9th Scientific Workshop of the European Crohn's and Colitis Organisation (ECCO): Artificial Intelligence in Endoscopy, Radiology and Histology in IBD Diagnostics.

While AI is set to substantially advance IBD diagnostics, various challenges such as heterogeneous datasets, retrospective designs and assessment of different endpoints must be addressed. Implementation of novel standards of reporting may drive an increase in research quality and overcome these obstacles.

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Results of the 9th Scientific Workshop of the European Crohn's and Colitis Organisation (ECCO): Artificial Intelligence in IBD: Regulatory and Methodological Considerations.

Topics covered include: potential clinical application-focused algorithm design; ethical, moral and legal considerations; regulatory agency perspectives; an overview of regulatory submission and consideration of reimbursement. By providing clinicians with a primer to key regulatory and methodological considerations, we hope to accelerate knowledge translation and implementation of AI-enabled digital health innovations in clinical practice and ultimately improve outcomes for people living with and caring for those living with IBD.

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Results of the 9th Scientific Workshop of the European Crohn's and Colitis Organisation (ECCO): Artificial Intelligence in medical management and precision medicine.

While AI and multiomic approaches hold substantial promise for advancing IBD management and research, further refinement is necessary to ensure content validity and address safety concerns, thereby allowing integration of AI into clinical workflows and safeguarding of data privacy. Future research should prioritise the integration of diverse omic data, conduct of longitudinal studies and validation in large and diverse cohorts.

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Results of the Ninth Scientific Workshop of the European Crohn's and Colitis Organisation (ECCO): Artificial intelligence in IBD surgery: opportunities and limitations.

We need to be mindful of the potential challenges in implementation and acceptability of these technological advances and put in mitigating measures to ensure transparency and equitable access. Global collaboration will be the cornerstone for such ventures.

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Liver Transpl

30-year follow-up of immunosuppression modulation: Impact on graft fibrosis and anti-HLA antibodies after pediatric liver transplantation.

Conversely, persistent fibrosis in the IS-resumption group highlights the limitations of conventional IS strategies. Serial histological evaluations and antibody monitoring would be helpful for long-term IS management in pediatric liver transplant recipients.

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Coproducing a health advocate intervention for pediatric liver transplant recipients using a human-centered design.

Using structured design methodology, we designed a prototype navigator role for pediatric liver transplant care teams. Future studies should test the effectiveness of this navigator role in improving posttransplant outcomes.

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HepB-CpG vaccination: An alternate strategy to life long antiviral therapy in patients transplanted for chronic Hepatitis B.

Long term protection is sustainable with periodic boosters. New biomarkers for HBV allow earlier detection of underlying viral transcription and may promote better understanding of vaccine failure.

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Liver transplantation indications and strategies in polycystic liver disease: A european survey.

Uniform PLD-specific LT criteria in Europe are lacking. While recurrent liver cyst infections, decreased quality of life, and malnutrition are widely recognized as crucial LT indications, they are insufficiently reflected in existing criteria, contributing to unequal access to LT. Moreover, considerable variation exists in liver-kidney transplantation for ADPKD patients, with a current lack of evidence to support one approach over another.

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Tumor burden and frailty: No association in liver transplant candidates with hepatocellular carcinoma.

Patients with HCC awaiting liver transplantation, who generally have well-compensated liver disease, may therefore exhibit a distinct frailty profile-driven by non-hepatic comorbidities rather than by liver failure or tumor burden. These findings support the need for HCC-specific frailty research to guide evaluation and management.

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Pancreas

Frailty as a Predictor of Outcomes in Patients with Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis.

Frailty assessments can be utilized as a predictor of outcomes and serve to guide clinical decision-making when determining prophylactic measures in patients undergoing ERCP who may be at risk for PEP.

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High Rate of Exocrine Pancreatic Dysfunction in Pediatric Patients with Diabetes Mellitus.

The co-existence of exocrine and endocrine pancreatic disease occurred in 3.5% of diabetes patients. The risk of pancreatitis occurring after diabetes was 1%, a rate 100 times higher than the general pediatric population (0.01%). Future studies are needed to determine the specific mechanisms involved in the connection between endocrine and exocrine pancreatic disease in children.

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N-acetyltransferase 10 Promotes Pancreatic Cancer Progression Through ZEB1/MT1-MMP Axis.

Our study highlights the pivotal functions of NAT10 in the progression of PC and reveals the underlying epigenetic mechanism that NAT10 promotes metastasis via ZEB1/MT1-MMP axis.

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Pancreatic and Peripancreatic Neural-Crest Derived Tumors: An Updated Contemporary Single Center Experience.

Paragangliomas have malignant potential and should be managed with an oncologic resection. Accurate preoperative diagnosis using EUS-FNA and nuclear imaging is crucial for recommending the appropriate surgical intervention and minimizing surgical morbidity.

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Stroke in Patients with Unresectable Pancreatic Cancer Undergoing Chemotherapy: Clinical Characteristics and Risk Assessment.

Stroke within 180 days occurred in 3.2% of patients and was commonly associated with discontinuation of chemotherapy and short survival. The combined score calculated with D-dimer and CA 19-9 levels predicted the stroke risk in pancreatic cancer patients receiving chemotherapy.

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Pancreatology

A porcine model of acute necrotizing pancreatitis.

The porcine model for acute necrotizing pancreatitis described here shows many parallels to spontaneous human disease and its systemic complications and may thus serve as a good model to assess the efficacy of novel pharmaceutical agents for the treatment of acute pancreatitis in humans.

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Acinar cell scoring on histology of the pancreatic stump reinforces subjective texture assessment during pancreatoduodenectomy to predict post-operative pancreatic Fistula.

Objective acinar cell density assessment highlights discrepancies in traditional tactile evaluations for predicting POPF. AS strengthens the subjective findings of pancreatic texture evaluation in patients undergoing PD.

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Association between intra-tumoral microbiome and genetic alterations in intraductal papillary mucinous neoplasms of the pancreas.

This study suggest that the intratumoral microbiome may be linked to the genetic characteristics of IPMNs and potentially contribute to their malignant progression.

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Genetic evidence for the causal impact of immune cells on pancreatic neuroendocrine tumors and the mediating effects of cathepsins.

This study provides novel insights into the causal roles of immune cell traits and cathepsins in pNETs progression. The findings highlight potential targets for therapeutic intervention, emphasizing the complex interplay between the immune system and tumor biology in pNETs.

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Normal-fat versus fat-restricted diets in patients with acute pancreatitis: A randomized controlled study (NouRish-AP study).

The trial was registered, and the protocol is available online at Thaiclinicaltrials. org (Identifier: TCTR20230926008).

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P62/Sequestosome1 deficiency disrupts antioxidant and stress homeostasis during acute pancreatitis without exacerbating inflammation.

These findings suggest that while p62 deletion does not affect overall AP severity, it compromises redox homeostasis and metabolic recovery, highlighting a protective role for p62 during pancreatic injury.

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Sequential nutrition intervention guided by nutritional risk screening improves outcomes following CyberKnife radiotherapy for pancreatic cancer: A randomized controlled trial.

Sequential nutrition intervention guided by nutritional risk screening effectively improves nutritional status, immune function, and QoL while reducing complications in pancreatic cancer patients undergoing CyberKnife radiotherapy, warranting clinical application.

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TSH as a novel biomarker for recurrence of hypertriglyceridemia pancreatitis: a clinical predictive tool linking lipid dysregulation to inflammation.

Elevated TSH was likely to be an independent risk factor for HTG-AP recurrence. In addition, the new nomogram model based on TSH level shows high accuracy in predicting HTG-AP recurrence, which is expected to provide certain help for clinical prevention and treatments.

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Water avoidance stress exacerbates orthotopic pancreatic cancer growth by suppressing cytotoxic T lymphocyte infiltration.

Our results suggest that in the peritumoral region, WAS suppressed anticancer immunological responses by the suppression of TNF-α secretion, ICAM-1 expression, lymphocyte adhesion, cytotoxic T lymphocyte infiltration, and IFN-γ secretion, thereby promoted pancreatic cancer growth. Inducing the upregulation of adhesion molecules and augmentation of cytotoxic T cell recruitment may lead to the development of new treatments for pancreatic cancer.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Pancreatology

Type 3c diabetes associated with chronic pancreatitis: A narrative review.

For severe complicated T3cDM, a basal-bolus approach with insulin therapy is advocated. Promising future approaches includes metabolome-based prediction of progression of prediabetes to T3cDM, and treatment with PP and fecal microbial manipulation.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Clinical Characteristics and Treatment Patterns in a Large Cohort of Patients with Metastatic Crohn's Disease.

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Modified Multiplier of SES-CD: Does Complex Better the Simple?

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Resolving Loss of Response to Ustekinumab in Crohn's Disease: POWER Through or Switch Treatment?

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Liver Transpl

Closing Time.

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Letter to the Editor: Alcohol-associated liver disease, social vulnerability index, and liver transplantation.

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Letter to the Editor: Transjugular intrahepatic portosystemic shunt in paediatric liver transplant candidates- feasible and successful.

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Moving upstream: Understanding barriers to living donor liver donation in Hispanic and non-Hispanic candidates.

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Policy Corner: Artificial intelligence in liver transplantation.

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Reply: Alcohol-associated liver disease, social vulnerability index, and liver transplantation.

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Revealing Disparities: American Indians are deferred and denied for Liver transplant at a higher rate due to psychological reasons.

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Pancreas

Bariatric Surgery in Chronic Pancreatitis: Increased Exocrine Risk without Reduced Cancer Incidence.

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Characterization of Pancreatic Cystosis Phenotype in People With Cystic Fibrosis.

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Comment on: "The Significant Impact of Fibrinogen-C-Reactive Protein--Albumin Ratio on the Long-Term Outcomes After Pancreatic Resection for Pancreatic Cancer".

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Decisional Control Preferences in Managing Intraductal Papillary Mucinous Neoplasms of the Pancreas.

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Frailty in Chronic Pancreatitis and Its Impact on HealthCare Utilization and Inpatient Outcomes: A Nationwide Analysis.

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Outpatient Utilization Patterns for Pancreatic Cancer Suggest Regional and Hereditary Disparities in Appalachian vs non-Appalachian Kentucky.

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Response to Letter to Editor "Accurately Predicting Outcomes in Acute Necrotizing Pancreatitis With Walled-Off Necrosis Patients" by Shangzhu Chen and Chengdong Tang.

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When Pancreatitis Hits Hard: High Healthcare Demands in Appalachian Kentucky.

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Pancreatology

Cost-effectiveness of liposomal irinotecan (nal-IRI) combined with 5-fluorouracil and leucovorin in second or subsequent lines for metastatic pancreatic cancer in Italy. It can be done.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

Structural funding bias in red meat research: The elephant in the room.

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Pancreas

Pancrelipase Treatment of Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: Rationale and Methodology of a Real-World, Prospective, Observational Study.

Pubmed   Journal   ReadQx   PMC

Pancreatology

Pancreatic hydatid cyst: An ongoing enigma.

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Response to the Letter to the Editor regarding our manuscript: "Perilesional branch duct dilation as a hallmark MRCP feature for differentiating high-grade PanIN from low-grade PanIN".

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